The prostate cancer diagnose consist of giving it a grade and a stage. Grading is different than staging that represents the determination of the extent for the cancer or the spread to other body parts. For staging of prostate cancer are used two systems The Whitmore-Jewett with staging from A to D and sub stages for précised definition. The other system is TNM in which T represents the extent of primary tumor, N the presence or absences in nearby lymph nodes or glands of metastasis, and M the presences or absence of distant metastasis.

The angiogenesis is the process from witch can develop prostate cancer metastasis. When malignant cells will spread into another body with the formation of new blood vessels we can call it angiogenesis. This malignant cell will become lodged in lymph nodes and bones. From that point the cells will start dividing without control.

During the advanced prostate cancer is the most likely to occur metastasis.  This refers to the moment where prostate cancer has left the prostate gland and the neighboring organs. Advanced prostate cancer can be associated with bone metastasis, lymph node metastasis that can be local or distant and advanced prostate cancer bone metastasis. The function of lymph nodes is to filter the fluid called lymph. The lymph contains white blood cells and circulates through the lymphatic system. When cancerous cell circulate through the body the lymph node can trap them and then the cancerous cells begin their division thus resulting lymph node metastasis.

When we speak about lymph node metastasis we can divide it into local and distant. The clinical stage N1 designates the local lymph node metastasis. The two lymph nodes that lay either side of the bladder are close to prostate gland and the metastasis is considered local. When the cancerous cell begins development end multiplication in other lymph node we speak about distant metastasis.

This metastasis is noted with the stage M1a. Stiffness, frequent soreness in hips, thighs or lower back these are the symptoms of advanced prostate cancer. The pain is felt differently by every patient.  Some of them have to begin an external radiation therapy or chemotherapy to alleviate the pain that is associated with bone cancer.

Prostate cancer with bone metastasis is classified according his origin. Patient with advanced prostate cancer are prone to development of bone cancer.  Many patient will die having prostate cancer rather than because of it and will not reach the advanced stages of prostate cancer. Viable options of treatment are watchful waiting. Trough chemotherapy the dividing cells are quickly destroyed. The effectiveness of chemotherapy treatment lies on the speed of malignant cell dividing; if they divide faster the chemotherapy will be more efficient.

Small and otherwise undetectable lymph node metastases in patients with prostate cancer can be detected using High resolution MRI with magnetic nano-particles. The advanced prostate cancer can be declared when the disease has reached clinical stage T3 and T4. In the early stages of disease the prostate cancer symptoms can be caused by advanced prostate cancer with bone metastasis or lymph node metastasis. The M and N clinical staging are what usually doctors check for metastasis and lymph node metastasis.